Allergies and Asthma (2023)

The Center for Innovation in Global Health at Stanford University and the Stanford Woods Institute for the Environment, together with the Center for Climate Change and Planetary Health at the London School of Hygiene and Tropical Medicine, have joined forces. to create a newPostdoctorate in Planetary Healthto support early-career researchers tackling pressing problems in this emerging field.

Planetary health is the health of human civilization and the state of the natural systems on which it depends. Urgent threats to human health arise from the impacts of human-caused climate and environmental change, including air pollution and the loss of food-pollinating insect species. These threats disproportionately affect under-resourced communities, where people suffer dangerous consequences such as heat stress, reduced access to clean water, and malnutrition.

Research in the field of planetary health is developing rapidly and requires new approaches that focus on developing evidence for policy and real-world interventions. The institutes leading this new fellowship in planetary health are leaders in the field, and their collective expertise brings together more than 100 scientists active in planetary health issues and policy solutions.

While fellowships are typically housed at an institution, this partnership offers researchers a unique opportunity to engage in a variety of disciplines and conduct innovative research. Planetary Health Fellows will spend time with LSHTM mentors and senior Stanford faculty. The fellows will also participate in research with local partners in countries such as Bangladesh, The Gambia, India, Uganda and Zimbabwe.

“Running a fellowship program at LSHTM and Stanford will help us address some of the biggest issues in human and planetary health,” said Dr. Michele Barry, Stanford's senior associate dean for global health. “I would love to see this as a way to expand planetary health research capacity among beginning scientists in low- and middle-income countries, and I hope this grant helps inspire new ways of thinking that will build a resilient and sustainable planet. . . ”

“This joint initiative emphasizes planetary health as an urgent and critical area of ​​research,” said Professor Alan Dangour, Director of LSHTM's Center for Climate Change and Planetary Health. "In addition to inspiring planetary health researchers to think in new ways, the research will help us generate high-quality, evidence-based solutions for the health of people and the planet."

Funding comes from the Gordon and Betty Moore Foundation, the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, and Bob and Kathy Burke.

The fellowship program is open to researchers from anywhere in the world who have completed their PhD in the last three years. The call for applications for the Fellowship in Planetary Health will open in June 2020 and the two-year Fellowship will start in late 2020 or early 2021.

• Results from a Phase 3 clinical trial of AR101, a highly characterized pharmaceutical-grade peanut OIT formulation, have now been published in theNew England Journal of Medicine.AR101, developed by Aimmune Therapeutics, is designed to provide consistent dosing of the major peanut allergenic proteins (Ara h1, Ara h2, and Ara h6). The Sean N. Parker Center for Allergy and Asthma Research at Stanford University was one of the centers where the study was conducted, and this study builds on Phase 1 and 2 studies that we and others have conducted around the world. world. The children and adolescents included in the study were severely allergic to peanuts. After one year of therapy, 67% of those treated with AR101 tolerated approximately 2 peanuts without dose-limiting symptoms compared to 4% of those treated with placebo. Patients also had less severity of symptoms during peanut exposure in the meal-out challenge than placebo.
• Read more aboutNew York Timesis inCNN.
  

On April 26, 2018, the Center was honored to host the Center's second Annual Forum for the community, including patients, parents, and physicians. Dr. Kari Nadeau, Dr. Tina Sindher Dr. Esteban Galli, Dr. Nielsen Fernandez-Becker, Marté Matthews, Andrew Long, and Whitney Block gave the audience in-depth presentations on allergies, asthma, and related gastrointestinal disorders. Lectures included discussions of recent food allergy findings, emerging diagnoses, eosinophilic esophagitis (EoE), coping with the emotional impact of food allergy, potential biologics and therapies, and recruitment trials.

Download the 2018 State of Downtown Forum Slides

In November 2017, the World Allergy Organization (WAO) designated Stanford University's Sean N. Parker Center for Allergy and Asthma Research asWAO Center of Excellence.

Read more about this distinction

The World Allergy Organization (WAO) is an international organization whose members consist of 97 regional and national societies of allergy and clinical immunology from around the world. By collaborating with member societies, WAO offers direct educational programs, symposia and conferences to members in nearly 100 countries around the world.

AWAO Center of ExcellenceThe distinction intensifies and accelerates multidisciplinary scientific and clinical innovation, education, and advocacy worldwide, providing excellence in education, research, and training for multiple stakeholders in allergy, asthma, and clinical immunology.

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On February 15, 2017, Julia and David Koch announced a generous $10 million grant to establish a new facility at Lucile Packard Children's Hospital Stanford for clinical research. The unit will operate out of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, home of the innovative allergy and asthma clinical trials led byKari Nadeau, MD, PhD.

LerMore about the impact of this gift

Nadeau directs the Sean N. Parker Center for Allergy and Asthma Research, one of the world's first coordinated efforts to combine laboratory research, clinical research, and compassionate patient care across all types of allergies. While Nadeau conducts laboratory research on the Stanford University campus, she currently conducts clinical research off campus at a Packard Children's licensed facility within El Camino Hospital in Mountain View.

Thanks to a generous gift from the Kochs, Nadeau and his team will expand their clinical research into a redesigned unit at Lucile Packard Children's Hospital Stanford in 2018. Packard Children's is currently nearing completion of a major expansion that will subsequently free up space for research in Nadeau. . Located on the Stanford campus, the new clinical trial site will allow Nadeau's team to expand research to better understand the underlying cause of allergies and develop a lasting cure. It will also put them within easy reach of Nadeau's research lab and other physicians and researchers working together at Stanford to advance allergy and asthma research.

"We made this gift with the goal of bringing better and safer treatments to more children and adults with dangerous allergies," said Julia F. Koch, whose family has experienced firsthand the anxiety of living with food allergies, as well as life : altering the effects of a clinical trial to safely desensitize allergies. "Through this gift, we hope to advance groundbreaking research and enable more individuals and families to enjoy fuller lives."

"Lord and Mrs. Koch's careful investment will have a tremendous impact on the care and treatment we provide to children and families with allergies and asthma," says Nadeau. "Children and families with food allergies often live with the constant fear of threats to life. reactions. life. We are determined to use innovative research and compassionate care to advance science in transformative ways and ensure a more secure future. I am immensely grateful to Mr. and Mrs. Koch for the gift of establishing a new clinic, who play a critical role in advancing this work at the Sean N. Parker Center for Allergy and Asthma Research Together, we will make a a difference not only for those participating in clinical trials at Lucile Packard Children's Hospital Stanford, but for all people with allergies who may one day benefit from research into better, safer, and longer lasting therapies.”

Allergies and asthma are on the rise around the world, including in the United States. Allergies occur at all ages and can range from allergic conjunctivitis, allergic rhinitis, allergic asthma, and allergic gastrointestinal disease to drug allergies and food allergies. Serious food allergies are a growing epidemic, with rates doubling in the last decade. About one in three Americans suffers from some type of allergy, and medically diagnosed food allergies affect one in 12 American children under the age of 21 and one in 50 adults. Of people with a food allergy, approximately 25% will have a near-fatal anaphylactic reaction at some point in their lives. It is estimated that $25 billion is spent annually on the care of reactive food allergies.

Nadeau, who is also a professor of medicine and pediatrics at the Naddisy Foundation at Stanford University School of Medicine, developed the first multi-food allergy combination therapy for patients with more than one food allergy. The new Packard Children's facility will bring its staff closer to Stanford University colleagues in immunology, gastroenterology, ENT, chemistry, bioengineering, pathology, pulmonology, and genetics who are contributing to this important collaborative work.

For more information, please contact usjennifer yuan, Lucile Packard Foundation for Children's Health

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The National Academies of Sciences, Engineering and Medicine convened an ad hoc committee of experts to examine critical issues related to food allergies. The resulting report, published on November 30, 2016,Finding a path to safety in food allergy: assessing the global burden, causes, prevention, management, and public policy, collects and evaluates scientific evidence on the prevalence, origins, diagnosis, prevention, and treatment of food allergies, and makes recommendations to policymakers, industry leaders, and others to create a safe environment for people with food allergies .

Read a statement from Dr. Stephen Galli and download the full report (free)

The following is a statement from Dr. Stephen Galli, Mary Hewitt Loveless, Professor M.D. at Stanford School of Medicine and Professor of Pathology and of Microbiology and Immunology, who served as a member of the Institute of Medicine committee that wrote this report.

It has been a privilege and honor to serve on this committee and to work on producing the report with the other members of the committee, the dedicated and effective staff of the national academies, and the many federal and private funders of this important effort.

As described in the brief summary of the report released today, and as set out in substantial detail in the report itself, the committee concluded that now is the time to take a series of steps that, if successfully implemented, promise to significantly improve the quality. of life of those with food allergies. Success in this effort will require the immediate and responsive cooperation of many stakeholders, including federal and state agencies, whose careful work will be necessary to effect these changes. I encourage everyone with an interest in the problem of food allergies to read the report and do their part to encourage rapid implementation of the committee's recommendations.

Addressing this serious problem is just as important as implementing the report's recommendations; Ultimately, finding ways to effectively treat or, ideally, prevent the onset of food allergies will require innovative research to advance our understanding of the origins of this disorder and design better ways to manage, prevent, or treat it. I predict that with Kari Nadeau's visionary leadership, the Sean N. Parker Center for Allergy and Asthma Research at Stanford will continue to make an important contribution to worldwide efforts, by talented researchers at many institutions, to bring relief to those who suffer. of this terrible condition disorder.

The full report can be viewed along with slides from the November 30, 2016 presentation that highlight the report's approach and recommendations.downloaded here (free).

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We met our match! We are pleased to announce that we have raised $1.2 million to fulfill our Hartman Family Foundation Challenge Grant. Through the generous 1-to-1 contribution of the Kim and Alan Hartman Foundation and many other generous donors, we have raised a total of $2.4 million to directly support this important step in making a food allergy "shot" a reality.

Read more about this inspiring peptide "vaccine" Immunotherapy support

Stay tuned for updates on this groundbreaking study testing an approach called peptide "vaccine" immunotherapy. Similar to a tuberculosis test, the food allergy "shot" would be placed under the skin to stimulate a specific set of immune cells and permanently reduce or suppress allergic reactions.

“This could be a breakthrough for our field, and we are grateful to the Hartman Foundation for making this possible through their donation,” said Dr. Kari Nadeau, director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University.

Read more about Kim and Alan Hartman's inspiring support of the Center and Dr. Kari Nadeau.

94% of the Center's funding comes from philanthropy. Ongoing support helps patients and their families every day by advancing science and research for innovative clinical trials, education and protocol outreach across the country, building infrastructure for the Center, and much more. For more information on our important funding priorities,Contact Lindsey Hincks.

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